debCAM - Deconvolution by Convex Analysis of Mixtures
An R package for fully unsupervised deconvolution of complex tissues. It provides basic functions to perform unsupervised deconvolution on mixture expression profiles by Convex Analysis of Mixtures (CAM) and some auxiliary functions to help understand the subpopulation-specific results. It also implements functions to perform supervised deconvolution based on prior knowledge of molecular markers, S matrix or A matrix. Combining molecular markers from CAM and from prior knowledge can achieve semi-supervised deconvolution of mixtures.
Last updated 24 days ago
softwarecellbiologygeneexpression
5.66 score 7 stars 13 scripts 272 downloadsOVESEG - OVESEG-test to detect tissue/cell-specific markers
An R package for multiple-group comparison to detect tissue/cell-specific marker genes among subtypes. It provides functions to compute OVESEG-test statistics, derive component weights in the mixture null distribution model and estimate p-values from weightedly aggregated permutations. Obtained posterior probabilities of component null hypotheses can also portrait all kinds of upregulation patterns among subtypes.
Last updated 24 days ago
softwaremultiplecomparisoncellbiologygeneexpression
4.00 score 1 stars 2 scripts 206 downloads